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KMID : 0361420100340010001
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Journal of Korean Academy of Rehabilitation Medicine
2010 Volume.34 No. 1 p.1 ~ p.9
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Effects of Enriched Environment on Locomotion and Cognition in Neonatal Rats with Hypoxic-Ischemic Encephalopathy
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Yang Shin-Seung
Sohn Min-Kyun
Kim Bong-Ok
Choi Pil-Soon
Kim Sung-Kyum
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Abstract
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Objective: To investigate the effect of environmental enrichment on the cognitive and motor development in the experimental hypoxia-ischemic encephalopathy neonatal rat model.
Method: Hypoxic-ischemic encephalopathy models were made in neonatal Sprague-Dawley rats at 3 days of age by ligating the unilateral carotid artery followed by inhalation of 8% oxygen and raised in the enriched environment (n=10), treadmill exercise (n=8) and non-stimulation (n=10) from the 3rd to 8th weeks of age. Neurobehavioral and histopathological changes were compared.
Results: The neurobehavioral tests of the rats with hypoxic- ischemic encephalopathy showed prolonged latencies of achievement for cliff avoidance and negative geotaxis (p＜0.05). Persisting abnormality into adult life of limb placing improved in exercise and enriched environment groups and spatial learning and memory in a water maze recovered in the rats with enriched environment (p＜0.05). The density of dendritic spine increased in the hippocampus with enriched environment (p＜0.05).
Conclusion: The present study supports the possibilities of the positive effects after the enriched environment in the developing brain with hypoxic injury.
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KEYWORD
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Enriched environment, Hypoxic-ischemic encephalopathy, Neonate, Rat
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